CBDV

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• Cannabidivarin (CBDV) suppresses pentylenetetrazole (PTZ)-induced increases in epilepsy-related gene expression.

• Cannabidivarin-rich cannabis extracts are anticonvulsant in mouse and rat via a CB1 receptor-independent mechanism.

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Cellular Function

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• Anti-inflammatory potential of CB1-mediated cAMP elevation in mast cells.

• Cannabidiol, a therapeutic potential compound, inhibits the catalytic activity of cytochrome.

• Cannabidiol Targets Mitochondria to Regulate Intracellular Ca2+ Levels.

• Characterization of P-glycoprotein Inhibition by Major Cannabinoids from Marijuana.

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Cerebral Palsy

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• Survey Results of Pain Treatments in Adults with Cerebral Palsy.

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Cognition

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• Cannabidiol reduces host immune response and prevents cognitive impairments in Wistar rats submitted to pneumococcal meningitis.

• Effects of cannabis on cognitive function in patients with multiple sclerosis.

• Keep off the grass? Cannabis, cognition and addiction.

• Methods of the Pharmacological Imaging of the Cannabinoid System (PhICS) study.

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Colon Cancer

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• The endogenous cannabinoid, anandamide, induces COX-2-dependent cell death in apoptosis-resistant colon cancer cells.

• Cannabinoid Receptor Activation Induces Apoptosis through Tumor Necrosis Factor.

• Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer.

• Estrogenic induction of cannabinoid CB1 receptor in human colon cancer cell lines.

• Growth inhibition and induction of apoptosis in colorectal tumor cells by cyclooxygenase inhibitors.

• Induction of Apoptosis by Cannabinoids in Prostate and Colon Cancer Cells Is Phosphatase Dependent.

• Inhibition of colon carcinogenesis by a standardized Cannabis sativa extract with high content of cannabidiol.

• Possible endocannabinoid control of colorectal cancer growth.

• The cannabinoid δ9-tetrahydrocannabinol inhibits RAS-MAPK and PI3K-AKT survival signalling and induces BAD-mediated apoptosis in colorectal cancer cells.

• The endogenous cannabinoid, anandamide, induces cell death in colorectal carcinoma cells: a possible role for cyclooxygenase 2.

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Crohn's Disease

 

• Cannabis Alleviates Symptoms Of Crohn’s Disease.

• Cannabis finds its way into treatment of Crohn’s disease.

• Cannabis Induces a Clinical Response in Patients With Crohn's Disease.

• Treatment of Crohn’s Disease with Cannabis.

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Depression

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• Antidepressant-like and anxiolytic-like effects of cannabidiol: a chemical compound of Cannabis sativa.

• Antidepressant-like effect of Δ9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L.

• Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects.

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Diabetes

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• Cannabidiol Arrests Onset of Autoimmune Diabetes in NOD Mice.

• Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, inflammatory and cell death signaling pathways in diabetic cardiomyopathy.

• Cannabinoids Regulate Bcl-2 and Cyclin D2 Expression in Pancreatic β Cells.

• Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients.

• Novel Study Reports Marijuana Users Have Better Blood Sugar Control.

• Presence of functional cannabinoid receptors in human endocrine pancreas.

• The Endocannabinoid System and Plant-Derived Cannabinoids in Diabetes and Diabetic Complications.

• The endocannabinoid system in obesity and type 2 diabetes.

• The Endogenous Cannabinoid System Stimulates Glucose Uptake in Human Fat Cells via Phosphatidylinositol 3-Kinase and Calcium-Dependent Mechanisms.

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Drug Interactions

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• A Phase I, open-label, randomized, crossover study in three parallel groups to evaluate the effect of Rifampicin, Ketoconazole, and Omeprazole on the pharmacokinetics of THC/CBD oromucosal spray in healthy volunteers.

• Cannabis and its effect on anesthesia.

• Interactions between cannabidiol and commonly used antiepileptic drugs.

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Edema

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• Sex differences in anti-allodynic, anti-hyperalgesic and anti-edema effects of Δ9-tetrahydrocannabinol in the rat.

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Emesis

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• Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT1A somatodendritic autoreceptors in the dorsal raphe nucleus.

• Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT1A receptor activation.

• Interaction between non-psychotropic cannabinoids in marihuana.

• Regulation of nausea and vomiting by cannabinoids.

• The Effects of Cannabidiol and Tetrahydrocannabinol on Motion-Induced Emesis in Suncus murinus.

• The Nonpsychoactive Cannabinoid Cannabidiol Inhibits 5-Hydroxytryptamine3A Receptor-Mediated Currents in Xenopus laevis Oocytes.

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Endocannabinoid System

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• Abnormalities in neuroendocrine stress response in psychosis: the role of endocannabinoids.

• Agonistic Properties of Cannabidiol at 5-HT1a Receptors.

• Anandamide and 2-arachidonoylglycerol: Pharmacological Properties, Functional Features, and Emerging Specificities of the Two Major Endocannabinoids.

• Antiangiogenic Activity of the Endocannabinoid Anandamide: Correlation to its Tumor Suppressor Efficacy.

• An Update on Non-CB1, Non-CB2 Cannabinoid Related G-Protein-Coupled Receptors.

• Biphasic Effects of Cannabinoids on Acetylcholine Release in the Hippocampus: Site and Mechanism of Action.

• Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro.

• Cannabidiol is an allosteric modulator at mu- and delta-opioid receptors.

• Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors.

• Cannabinoid pharmacology: the first 66 years. 

• Cannabinoid receptors and endocannabinoids: Evidence for new players. 

• Cannabinoid Receptors CB1 and CB2 Form Functional Heteromers in Brain. 

• Cannabinoid system and cyclooxygenases inhibitors.

• Cannabis, a complex plant: different compounds and different effects on individuals.

• Cannabis and endocannabinoid modulators: Therapeutic promises and challenges.

• Care and Feeding of the Endocannabinoid System: A Systematic Review of Potential Clinical Interventions that Upregulate the Endocannabinoid System.

• Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes.

• Clinical endocannabinoid deficiency (CECD) revisited: can this concept explain the therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions?

• Dose-Related Differences in the Regional Pattern of Cannabinoid Receptor Adaptation and in Vivo Tolerance Development to Δ9-Tetrahydrocannabinol. 

• Endocannabinoid Signaling Regulates Sleep Stability.

• Endocannabinoid Binding to the Cannabinoid Receptors: What Is Known and What Remains Unknown.

• Endocannabinoid CB1 receptor-mediated rises in Ca2+ and depolarization-induced suppression of inhibition within the laterodorsal tegmental nucleus.

• Endocannabinoids and the haematological system.

• Endocannabinoid signalling and the deteriorating brain.

• Endocannabinoid System in First Trimester Placenta: Low FAAH and High CB1 Expression Characterize Spontaneous Miscarriage.

• Endothelium-dependent metabolism by endocannabinoid hydrolases and cyclooxygenases limits vasorelaxation to anandamide and 2-arachidonoylglycerol. 

• Enhanced discriminative stimulus effects of Δ9-THC in the presence of cannabidiol and 8-OH-DPAT in rhesus monkeys. 

• Estrogen Receptor Beta and 2-arachidonoylglycerol Mediate the Suppressive Effects of Estradiol on Frequency of Postsynaptic Currents in Gonadotropin-Releasing Hormone Neurons of Metestrous Mice: An Acute Slice Electrophysiological Study.

• Evidence for a physiological role of endocannabinoids in the modulation of seizure threshold and severity.

• Evidence that the plant cannabinoid cannabigerol is a highly potent α2-adrenoceptor agonist and moderately potent 5HT1A receptor antagonist.

• Fatty Acid-binding Proteins (FABPs) Are Intracellular Carriers for Δ9-Tetrahydrocannabinol (THC) and Cannabidiol (CBD).

• Hardwiring the Brain: Endocannabinoids Shape Neuronal Connectivity.

• Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes.

• Mitochondria: a possible nexus for the regulation of energy homeostasis by the endocannabinoid system?

• Modulating the endocannabinoid system in human health and disease - successes and failures.

• Neuropharmacology of the Endocannabinoid Signaling System-Molecular Mechanisms, Biological Actions and Synaptic Plasticity.

• Pharmacokinetics and Metabolism of the Plant Cannabinoids, Δ9-Tetrahydrocannibinol, Cannabidiol and Cannabinol. 

• Recent advances in cannabinoid receptor agonists and antagonists.

• Relationships between eicosanoids and cannabinoids.

• Role of the Cannabinoid System in Pain Control and Therapeutic Implications for the Management of Acute and Chronic Pain Episodes.

• Role and Function of Endocannabinoid System in Major Depressive Disease.

• Targeting the endocannabinoid system with cannabinoid receptor agonists: pharmacological strategies and therapeutic possibilities.

• The diverse CB1and CB2 receptor pharmacology of three plant cannabinoids: Δ9-tetrahydrocannabinol, cannabidiol and Δ9-tetrahydrocannabivarin.

• The Emerging Role of the Endocannabinoid System in Endocrine Regulation and Energy Balance.

• The endocannabinoid-CB receptor system: Importance for development and in pediatric disease.

• The endocannabinoid system and migraine.

• The Endocannabinoid System.

• The Endocannabinoid System as an Emerging Target of Pharmacotherapy.

• The Endocannabinoid System, Cannabinoids, and Pain.

• The endocannabinoid system drives neural progenitor proliferation.

• The endocannabinoid system in normal and pathological brain ageing.

• The endogenous cannabinoid system and its role in nociceptive behavior.

• The orphan receptor GPR55 is a novel cannabinoid receptor.

• The role of endogenous cannabinoids in the hypothalamo-pituitary-adrenal axis regulation: in vivo and in vitro studies in CB1 receptor knockout mice.

• The therapeutic potential of novel cannabinoid receptors.

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Endocrine System

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• Estrogenic induction of cannabinoid CB1 receptor in human colon cancer cell lines.

• Estrogen Receptor Beta and 2-arachidonoylglycerol Mediate the Suppressive Effects of Estradiol on Frequency of Postsynaptic Currents in Gonadotropin-Releasing Hormone Neurons of Metestrous Mice: An Acute Slice Electrophysiological Study.

• Gynecomastia and cannabis smoking.

• Marijuana: interaction with the estrogen receptor.

• Presence of functional cannabinoid receptors in human endocrine pancreas.

• The effects of delta9-tetrahydrocannabinol and cannabidiol on the metabolism of gonadal steroids in the rat.

• The Emerging Role of the Endocannabinoid System in Endocrine Regulation and Energy Balance.

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Epilepsy

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• Cannabigerolic acid, a major biosynthetic precursor molecule in cannabis, exhibits divergent effects on seizures in mouse. models. of epilepsy.

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